Mohamed Ibrahim Bassyouni
2020 / 7 / 25
New research may help explain the phenomenon of decreased infections in children, indicating the presence of prior immunity against SARS CoV2 in 62% of the uninfected sample of children, compared to 6% of adults. These interventional antibodies originate as a result of repeated infections with seasonal viruses. The majority of infections with these viruses occur in children .. Therefore, their immunity is relatively recent compared to adults whose antibody intake has decreased over time.
Many of the relevant human coronavirus (HCoVs) are endemic in humans, causing mild respiratory infections 1. Coronavirus 2 (SARS-CoV-2), the causative agent of the disease Coronavirus-2019 (COVID-19), is A modern animal infection quickly reached a pandemic. Animal insertion of new coronavirus is thought to occur in the absence of pre-existing immunity among the target population. Using various assays to screen for antibodies interacting with glycoprotein-SARV-CoV-2 Spike (S), we demonstrate pre-existing immunity in uninfected and exposed people to the new coronavirus. SARS-CoV-2S reactive antibodies were discovered, exclusively from the IgG class, in a sensitive flow cytometry-based manner in people without SARS-CoV-2 infection with recent HCoV infection and targeting sub-unit S2. In contrast, SARS-CoV-2 virus infection elevated IGG SARS-CoV-2S antibody levels, as well as the associated IgM and IgA antibodies throughout the 6-week observation period since symptoms appeared. Serum of HCoV patient reacted variable with SARS-CoV-2 S and nucleocapsid (N), but not with S1 subunitī-or-receptor binding domain (RBD) of S on standard enzymatic immunoassays. It is worth noting that the patient s HCoV serum exhibited specific neutralizing activity against SARS-CoV-2 S false patterns, according to the SARS-CoV-2 S-IgG levels binding and with efficiencies similar to those in the COVID-19 patient serum. Distinguishing between pre-existing and new antibody responses for SARS-CoV-2 will be critical for serology, serological spread and vaccine studies, as well as for our understanding of the sensitivity and natural infection of SARS-CoV-2 infection.